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  • Abstract
    suggested to influence risk of asthma and atopic disease in offspring Objective We examined the effect of BMI and GWG on risk of asthma wheezing atopic eczema AE and hay fever in children during the first 7 years of life Methods This was a cohort study of 38 874 mother child pairs from the Danish National Birth Cohort enrollment 1996 2002 with information from the 16th week of pregnancy and at age 6 months 18 months and 7 years of the child Odds ratios ORs with 95 CIs were calculated by logistic regression with adjustment for potential confounders Results During the first 7 years of life 10 4 of children developed doctor diagnosed asthma 25 8 AE and 4 6 hay fever Maternal BMI and to a lesser extent GWG were associated with doctor diagnosed asthma ever In particular BMI 35 adjusted OR 1 87 95 CI 0 95 3 68 and GWG 25 kg adjusted OR 1 97 95 CI 1 38 2 83 were associated with current severe asthma at age 7 years Maternal BMI was also associated with wheezing in offspring with the strongest association observed between BMI 35 and late onset wheezing adjusted OR 1 87

    Original URL path: http://cviva.dk/Publications/Harpso-et-al-2012.aspx (2016-04-30)
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  • Abstract
    and survival until 5 years of age DESIGN 4138 children born between 1987 and 1989 were visited at home every three months to collect information on nutritional status and vaccinations Since nutritional status was a determinant of time to vaccinations we adjusted for nutritional status in the analyzes of the association between vaccinations and mortality Setting 45 contiguous villages in Shirur Administrative Block in Pune District MAIN OUTCOME MEASURES Mortality rate ratios MRR for different vaccination status groups Results The study area has male preferential treatment but the female male mortality ratio varied between age groups with different pre dominant vaccines it was high in the age group in which diphtheria tetanus pertussis DTP vaccine predominates and low in the age group in which measles vaccine MV is given Children who followed the WHO recommended schedule of first BCG and then DTP vaccination were vaccinated earlier than other children p 0 01 Two thirds of the children had received BCG and DTP out of sequence i e BCG and DTP simultaneously or BCG after DTP Children who received BCG and DTP simultaneously or BCG as most recent vaccination had significantly lower mortality than children having DTP as the most recent

    Original URL path: http://cviva.dk/Publications/Hirve-et-al-2012.aspx (2016-04-30)
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  • Abstract
    is not considered in official statistics or assessments of programme performance In this observational cohort study from rural Guinea Bissau we assessed vaccination coverage and frequency of out of sequence vaccinations by 12 and 24 months of age using the Bandim Health Project s rural Health and Demographic Surveillance System It covers 258 randomly selected villages in all regions of Guinea Bissau Between 2003 and 2009 vaccination status by 12 months of age was assessed for 5806 children aged 12 23 months vaccination status by 24 months of age was assessed for 3792 children aged 24 35 months We found that only half of 12 month old children had completed all EPI vaccinations but coverage increased to 65 among 24 month old children Many children received vaccines out of sequence by 12 months of age 54 of BCG vaccinated children had received DTP with or before BCG and 28 of measles vaccinated children had received DTP with or after MV By 24 months of age the proportion of out of sequence vaccinations was 58 and 35 respectively for BCG and MV The low vaccination coverage and the high frequency of out of sequence vaccinations highlight the need to improve vaccination

    Original URL path: http://cviva.dk/Publications/Hornshoj-et-al-2012.aspx (2016-04-30)
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  • Abstract
    conducting a trial of BCG and vitamin A supplementation VAS at birth to low birthweight LBW children OPV was again lacking for a short period We used this natural experiment to test the previous observations Methods In the trial LBW infants were randomised to early or delayed BCG and VAS or placebo at birth We noted whether the children received OPV0 or not We compared children who received No OPV0 with those who received OPV0 in the 2 months before and the 2 months after the period without OPV Mortality was compared in Cox regression models providing adjusted hazard ratios aHR the immune response to BCG was assessed in Poisson models providing adjusted prevalence ratios aPR Results Ninety nine children received No OPV0 and were compared with 243 children who received OPV0 No OPV0 was associated with insignificantly higher mortality during the first year of life the aHR being 1 83 95 CI 0 93 3 61 The effect was similar in boys and girls Overall there was no significant association between No OPV0 and having a positive PPD response aPR 1 33 0 64 2 78 or a scar aPR 1 02 0 93 1 11 after BCG vaccination

    Original URL path: http://cviva.dk/Publications/Lund-et-al-2012.aspx (2016-04-30)
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  • Abstract
    months of age We evaluated whether MUAC or MUAC z score had the best ability to identify children with high short term mortality risk in Guinea Bissau Subjects Methods The Bandim Health Project visits children 3 monthly until 3 years of age MUAC is measured and deaths are registered We studied a high mortality cohort of children born in 1995 96 and a lower mortality cohort of children born in 2005 06 The prognostic ability of MUAC and MUAC z score to predict mortality within 1 and 3 months after the MUAC assessment were compared by area under the receiver operating characteristic curve sensitivity and positive predictive value Results Compared with MUAC z score MUAC identified as malnourished more girls than boys prevalence ratio PR 1 74 1 52 2 01 and more children aged 6 11 months than children aged 12 35 months 1 59 1 38 1 82 There was no difference in the prognostic ability of MUAC and MUAC z score to predict mortality for children aged 6 35 months The prognostic ability was higher when mortality was lower MUAC performed well in the youngest infants Conclusion In the age group 6 35 months MUAC and MUAC

    Original URL path: http://cviva.dk/Publications/Rasmussen-et-al-2012.aspx (2016-04-30)
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  • Abstract
    inpatients and outpatients attending for tuberculosis TB treatment within the study area of the Bandim Health Project a Health and Demographic Surveillance Site Our aim was to assess the variability between 2 physicians in performing the Bandim tuberculosis score TBscore a clinical severity score for pulmonary TB PTB and to compare it to the Karnofsky performance score KPS Method From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and or at 1 or more follow up visits 61 baseline and 130 follow up double assessments were obtained Results The inter observer variability of the TBscore 5 symptoms and 6 clinical findings varied from slight to almost perfect agreement For the TBscore all 3 severity classes SC I III were observed while the KPS only yielded 2 of its 3 possible classes The grading of PTB patients into severity classes showed moderate agreement for both the TBscore kappa w 0 52 95 confidence interval 0 46 0 56 and the KPS kappa w 0 49 95 confidence interval 0 33 0 65 The intra class correlation coefficient ICC was larger for the TBscore than for the KPS

    Original URL path: http://cviva.dk/Publications/Rudolf-et-al-2012.aspx (2016-04-30)
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  • Abstract
    24 months of follow up Within the placebo group we compared the mortality over the first 4 months and the full 2 years of follow up for different vaccination status groups with different likelihoods of additional vaccinations during follow up The frequency of additional vaccinations was assessed among children whose vaccination card was seen at 12 and 24 months of follow up Results Among children with a vaccination card more than 75 received missing DTP or MV during the first 12 months of follow up whereas only 25 received these vaccines among children with no vaccination card at enrolment Children without a card at enrolment had a significant threefold higher mortality over the 2 year follow up period than those fully vaccinated The small group of children with DTP3 4 but no MV at enrolment had lower mortality than children without a card and had the same mortality as fully vaccinated children In contrast children with 1 2 DTP doses but no MV had a higher mortality during the first 4 months than children without a card MRR 1 65 0 95 2 87 compared with the fully vaccinated children they had significantly higher mortality after 4 months MRR 2

    Original URL path: http://cviva.dk/Publications/Welega-et-al-2012.aspx (2016-04-30)
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  • Research
    establish a new systemic effect paradigm by documenting that the immune system is a learning entity which differs for males and females and which may be stimulated beneficially or deleteriously by vaccines and micronutrients Last revised 10 April 2012 Contact CVIVA Research Center for Vitamins and Vaccines Bandim Health Project Statens Serum Institut 5 Artillerivej DK 2300 Copenhagen S Phone 3268 8256 Email Printed from cviva dk on 30 04

    Original URL path: http://cviva.dk/Research.aspx?p=1 (2016-04-30)
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