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  • Najaaraq Lund
    birth to LBW children OPV was lacking for a short period We compared the 99 children who missed OPV0 with the 243 children enrolled from 2 months before to 2 months after the period with missing OPV and with all 2198 children who received OPV0 during the trial Missing OPV0 was associated with a tendency towards higher mortality during the first year of life the adjusted Hazard ratio aHR being 1 63 95 CI 0 83 3 19 in both boys and girls Paper II reports results from a randomised controlled open trial investigating whether VAS at birth instead of OPV0 could lower infant mortality for LBW boys Newborn boys were randomised to OPV0 or VAS and no OPV0 and followed for 12 months In the rainy season we detected a cluster of deaths in the VAS group and the trial was halted immediately The VAS group had significantly higher mortality than the OPV0 group in the rainy season HR 9 91 1 23 80 All deaths had had contact with the neonatal nursery of seven VAS boys enrolled in September six died within two months whereas only one died among the six OPV0 boys p for interaction 0 05 It was not possible to identify any specific pathogen which might have been the cause of the cluster of deaths Growth weight length arm circumference in the OPV0 group was significantly better until age 3 months Papers III and IV describe results from an open trial randomising 7000 NBW newborns to OPV0 and BCG as recommended or BCG alone Paper III describes growth of a subgroup of 1259 children and morbidity in a subgroup of 820 children Length weight head and arm circumference were measured in the anthropometry subgroup at 6 weeks 6 months and 12 months of age We

    Original URL path: http://cviva.dk/Research/PhD-Dissertations/Lund-2013.aspx (2016-04-30)
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  • Andreas Andersen
    in both randomization groups In this type of design analysis of covariance ANCOVA is the most powerful to detect a vaccination effect ANCOVA is a linear regression with the post vaccination measurement as outcome and the prevaccination measurement and the vaccination variable as covariates However there may be censored observations of both the pre and the post vaccination measurements and thereby both a censored outcome and a censored covariate We explored methods to conduct ANCOVA with censored variables in paper II Two immunological studies were analyzed in this thesis as a proof of concept In the REVAC study paper III the objective was to compare cytokine production between a group of BCG revaccinated children and a control group A further objective was to assess the effect of BCG revaccination on the pro anti inflammatory balance measured by the TNF α IL 10 ratio In a study of neonates with low birth weight LBW paper IV the children were randomized to receive BCG at birth or later according to local practice The objective was to examine associations between the child s immune response potential as measured by in vitro stimulated cytokine production and the risk of death A specific objective was to explore non linear associations In this case it posed a challenge to conduct a survival analysis with a censored covariate which is allowed to have a non linear effect Results The literature has shown that Tobit regression and multiple imputation MI are two valid methods to analyze univariate censored cytokine distributions To analyze a ratio like TNF α IL 10 when both variables can be censored we compared a multivariate Tobit method to a univariate Tobit method that uses clustered variance estimation to account for the inter variable correlation The two methods give almost identical results To conduct ANCOVA

    Original URL path: http://cviva.dk/Research/PhD-Dissertations/Andersen-2012.aspx (2016-04-30)
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  • Research Year Student - the Basics
    live one year in one of the poorest countries in Africa Guinea Bissau ambitions about writing scientific articles in English the will to make a difference humour talent for languages your feet on the ground and a warm heart Minimum length One year research year students Shorter stays not an option e g 3 6 or 9 months Funding Bandim Health Project DOES NOT fund its students directly However we will assist in applying for salary and research travel expenses Yet we expect the student to take a leading role in fund raising We may offer A research year at Bandim Health Project Students join different projects in particular in relation to child vaccination vitamin A supplementation tuberculosis HIV AIDS and much more You will collaborate with one or more students PhD researchers or senior researchers from Guinea Bissau and Denmark in a very active demanding and challenging research environment In general our students publish at least one article after their research year Eligibility Any nationality If you are interested then send us an application along with the most recent transcript from your university and your CV including information about previous stays in low income countries and language skills to

    Original URL path: http://cviva.dk/Opportunities/research-year-student-unsolicited.aspx (2016-04-30)
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  • 2nd workshop
    Emerging Immunologic Mechanisms Optimmunize workshop participants August 2012 Copenhagen Workshop participants Andrew Prentice London School of Hygiene and Tropical Medicine Arnaud Marchant University of Bruxelles Bastiaan Blok Radboud University Nijmegen Medical Center Catharina Ross Penn State University Christine Stabell Benn Research Center for Vitamins and Vaccines Dorthe L Jeppesen Hvidovre Hospital Ed Clarke MRC The Gambia Eleanor Fish University of Toronto Frank Shann Melbourne University Hilton Whittle London School of Hygiene and Tropical Medicine Ian Marriott UNC Charlotte Katie Flanagan Monash University Kristoffer Jarlov Research Center for Vitamins and Vaccines Liisa Selin University of Massachusetts Medical School Magdalena Plebanski Monash University Maria Yazdanbakhsh Leiden University Medical Centre Mihai Netea Radboud University Nijmegen Medical Center Mogens Claesson University of Copenhagen Nigel Curtis Melbourne University Ofer Levy Harvard Medical School Peter Aaby Bandim Health Project Reinout van Crevel Radboud University Nijmegen Medical Center Saad Omer Emory University Sabra Klein John Hopkins University Sarah Tufton Institute of Child Health London Sarah Rowland Jones Oxford University Steven Smith London School of Hygiene and Tropical Medicine Tobias Kollmann Child Family Research Institute Last revised 8 August 2012 Optimmunize Contact Optimmunize Optimmunize Research Center for Vitamins and Vaccines Bandim Health Project Statens Serum Institut 5 Artillerivej

    Original URL path: http://cviva.dk/Optimmunize/2nd-workshop.aspx (2016-04-30)
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  • 1st workshop
    Peter Aaby Indepth Network Apartado 861 1004 Bissau Codex Guinea Bissau Gert Almind Novo Nordisk Foundation Copenhagen Denmark Christine Stabell Benn Bandim Health Project Statens Serum Institut Copenhagen Denmark Jacobus Boomsma University of Copenhagen Mogens Claesson University of Copenhagen Hazel Dockrell London School of Hygiene and Tropical Medicine Eleanor N Fish University Health Network Department of Immunology University of Toronto Toronto Ontario Canada Katie L Flanagan MRC Laboratories The Gambia Kosuke Kawai Harvard School of Public Health USA Sabra L Klein Department of Molecular Microbiology and Immunology The Johns Hopkins Bloomberg School of Public Health Baltimore MD USA Henrik Leffers University of Copenhagen Arnaud Marchant Institute for Medical Immunology Université Libre de Bruxelles Bruxelles Belgium Ian Marriott Department of Biology University of North Carolina at Charlotte Charlotte NC USA Jennifer Moisi Centre for Geographic Medicine Kilifi Kenya Andrew Prentice International Nutrition Group London School of Hygiene and Tropical Medicine London UK and Keneba The Gambia Liisa Selin University of Massachusetts Medical School Worcester MA USA Niels Erik Skakkebæk Department of Growth and Reproduction Rigshospitalet Copenhagen Denmark Anita Van Den Biggela University of Western Australia Hilton Whittle MRC Laboratories PO Box 273 Fajara The Gambia Maria Yazdanbakhsh Leiden University Medical Centre

    Original URL path: http://cviva.dk/Optimmunize/1st-workshop.aspx (2016-04-30)
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  • 2016
    today is Andreas Rieckmann from CVIVA Bandim He will give the presentation Positive bivirkninger af vaccinerne mod tuberkulose og kopper Place Copenhagen City Hall Registration on email NB The four talks are all in Danish Read more in their invitation here Possible negative effects of new malaria vaccine for girls 28 April 2016 The RTS S vaccine is modestly effective at reducing clinical malaria in children and was recently approved by EMA However the subsequent release of the overall mortality data worryingly show that the vaccine is associated with increased overall mortality for girls Tonight in Copenhagen Peter Aaby gives a talk in Dansk Medicinsk historisk Selskab 16 March 2016 Lessons for the past and for the future En gentolkning af infektioner og vaccinationer Time 16 March 19 30 Place Auditoriet Kirurgisk Akademi Medicinsk Museion Bredgade 62 The presentation is in Danish Congratulations on an outstanding article Journal of Leukocyte Biology 20 January 2016 Journal of Leukocyte Biology points out the CVIVA article Vitamin A induces inhibitory histone methylation modifications and down regulates trained immunity in human monocytes as the most accessed papers in the last six months since publication It is number one overall CVIVA Statens Serum Institut 5

    Original URL path: http://cviva.dk/News/2016.aspx (2016-04-30)
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  • 2015
    novel The Arc of the Swallow as one of the best mysteries of 2015 Here is a link to the book list from The Wall Street Journal Read all about the novel in this Bandim Health Project news Public lecture by Christine Benn at the Royal Danish Academy of Sciences and Letters NOV 30 20 November 2015 Christine Benn is giving a public lecture on vaccines at the Royal Danish Academy of Sciences and Letters Please feel free to participate NB The lecture is in Danish Christine Benn invited to give prestigous plenary talk at the ESCAIDE conference 13 November 2015 European Scientific Conference on Applied Infectious Disease Epidemiology ESCAIDE is taking place this week in Stockholm Sweden Prof Christine Benn was invited to give one of the prestigous plenary talks at the conference Read more about the different speakers at their website The first child was enrolled in the new BCG rural study on November 7 10 November 2015 The BCG rural study will study the effect of BCG and OPV on early infant mortality and morbidity All children will receive a home visit by a study nurse shortly after birth Optimmunize satellite meeting 9 November 2015 The Optimmunize consortium had a satellite meeting in Guinea Bissau from October 30 November 2 to discuss progress and further initiatives Among the participants were Frank Shann AU Hilton Whittle UK Tobias Kollman Eleanor Fish and Nelly Amenyogbe CAN and Rob Arts and Bastiaan Blok NL along with researchers from Bandim Health Project CVIVA Vacancy Post doc and PhDs for research projects on non specific effects of vaccines 28 October 2015 See the job advert on the website of Statens Serum Institut Deadline 8 November 2015 Vacancy Biostatistician for research projects on non specific effects of vaccines 27 October 2015 See the

    Original URL path: http://cviva.dk/News/2015.aspx (2016-04-30)
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  • Vacancy: Biostatistician for research projects on non-specific effects of vaccines
    research projects on non specific effects of vaccines NEWS 2016 2015 2014 2013 2012 Close Share Facebook Google LinkedIn Twitter Vacancy Biostatistician for research projects on non specific effects of vaccines 27 October 2015 See the job advert on the website of Statens Serum Institut CVIVA Statens Serum Institut 5 Artillerivej 2300 Copenhagen S P 3268 8354 W http cviva dk E E mailadresser Du får denne besked fordi din

    Original URL path: http://cviva.dk/News/2015/2015_10_Biostatistician_for_research_projects.aspx (2016-04-30)
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